AI-Powered Financial Optimization in Healthcare
Key Highlights
- Midstream Health's AI platform integrates unstructured and structured data to provide proactive financial insights in healthcare settings.
- The partnership with CommonSpirit began with a rapid three-month assessment, pilot testing, and immediate implementation, demonstrating quick ROI.
- AI agents help identify cost-saving opportunities such as pricing errors, rebate discrepancies, and off-contract spend, reducing manual effort.
- The collaboration emphasizes long-term innovation, expanding AI applications beyond supply chain to other operational areas.
- Healthcare leaders are advised to start with limited pilots, establish strong governance, and focus on outcomes to successfully adopt AI solutions.
Earlier this year, California-based Midstream Health, an artificial intelligence (AI)-powered financial action platform, announced a partnership with the Chicago-based health system, CommonSpirit Health.
Midstream implements AI agents across back-office financial workflows, integrating spend and revenue operations within a single, AI-driven platform. It identifies financial opportunities such as pricing errors, rebate discrepancies, payer underpayments, and off-contract spend. Beginning with supply chain operations, CommonSpirit reported seeing measurable improvements within days.
Venkat Mocherla, Midstream’s co-founder and President, and Anuradhika Anuradhika, system vice president of strategic partnerships, CommonSpirit Health, spoke with Healthcare Innovation about the collaboration.
Last month, the Mount Sinai Health System, based in NYC and encompassing seven hospitals and more than 400 outpatient practices, announced a collaboration with Midstream Health as well, to implement real-time intelligence to enhance financial operations and improve workflow efficiency.
“Mount Sinai purchases and tracks supplies, equipment, and services well in excess of $1 billion a year to provide seamless patient care and advance medicine, research, and education,” said Vincent Tammaro, EVP and CFO of the Mount Sinai Health System in a statement about the partnership. “We recognize the value AI can bring as a supplement to our supply chain team, to ensure the pricing accuracy, efficiency, and value received from our contracting and purchasing processes. Receiving the full contract value of our rebates is an important component of managing supply expenses and mitigating the impact of rising inflation that contributes to healthcare unaffordability for our patients and communities.”
“We are honored to collaborate with Mount Sinai, an early Midstream adopter and recognized leader in using technology and innovation to transform healthcare,” Mocherla said in a statement. “Focused on rapid value generation, this collaboration is a great example of how agentic AI can go beyond providing insights—accelerating time to savings and advancing financial sustainability to help address the health care affordability crisis.”
Anuradhika, could you tell our audience about the partnership with Midstream Health? How did you come to this decision? What were some of the concerns you wanted to address with this platform, or what improvements did you want to make?
CommonSpirit Health is committed to the deliberate and intentional adoption of AI tools that directly support key business objectives. Our goal is not AI adoption for its own sake; rather, we aim to ensure these tools yield a positive, long-term influence on our operations, patients, and providers.
Our partnership efforts are informed by the gaps and opportunities identified by our teams. Midstream represents a successful culmination of these needs, as we collaborated with trusted partners to build effective solutions and unlock immediate ROI.
We became aware of Midstream through CommonSpirit Ventures, our innovation and investment arm, and immediately recognized its potential for co-development with our teams to address ways to make administrative decisions more efficient.
How is this tool different from others in your assessment?
Midstream leverages both frontier technology and the power of our internal data and administrative systems. We saw this unique partnership combination as a synergistic way to address the complex financial landscape of healthcare, and it has proven successful for us.
What has the timeline been from concept to implementation?
Our partnership began with a thorough assessment of the current state and requirements. By involving subject-matter experts and end users from the outset, we were able to test our thesis within three months and proceed to go live immediately following the pilot. This shows both the power of AI and of partnership, as many advances in healthcare take years to show promise and scale
What challenges did you experience, and how did you solve them?
Healthcare infrastructural data can be complex, especially for systems at our scale. As data quality directly guides the value of any output, our Information Technology teams play a critical role in ensuring the accuracy, validity, and linking of our data. Their efforts are essential in ensuring that the AI solutions we build render the highest possible value.
What has been some of the feedback from employees?
By deploying Midstream, we are able to effectively remove several administrative burdens from our team members. The result is a streamlined, more efficient workflow and improved employee satisfaction.
What has your overall experience been?
Overall, our experience has been very positive. The Midstream founders are dedicated to changing the industry for the better. It’s very helpful for systems like ours to have tools like this because every dollar we save means more resources to support our patients. We hope these early experiences with AI implementation can encourage innovation across the industry.
Do you have advice for healthcare leaders considering a similar solution?
When introducing a new AI tool, I recommend starting with a limited pilot. This allows for thorough testing and verification before moving to full implementation. Additionally, be sure that the adoption of any AI-based solution is guided by a robust governance structure that ensures rigor and continuous oversight.
Do you have a vision of future developments?
CommonSpirit has a rich history of developing companies alongside external entrepreneurs as well as championing innovations created by our own team members. We will continue to develop solutions that improve quality and enhance the ability for patients to access care.
With Midstream, we are looking to build on the success of our foundational infrastructure for other use cases within the supply chain and beyond. We see significant opportunities to inform real-time, data-backed decisions and bring efficiency to our teams through thoughtful AI agent deployments.
Venkat, could you provide some background?
I've spent the last 15 years thinking about how we innovate in healthcare. First, I was really thinking about how we move away from fee-for-service care and American healthcare to value. I helped start a company inside DaVita called Paladina, focused on direct primary care. I got to do global work. In the second chapter, I worked in Europe, the Middle East, and Canada for a research data consulting firm called the Advisory Board, where I got to see how not just innovation is done here in the US, but genuinely around the world. Ten years ago, I got really deep into applied machine learning work and AI work in healthcare. I got to see a company at the founding stage, Qventus, applying machine learning to help think about hospital operations. Right before Midstream, I spent time at Andreessen Horowitz, which is a large venture fund, thinking about the future of healthcare.
Midstream is a financial action platform. It's AI native. It’s as complicated as ever for a health system to manage, procure, and negotiate with multiple stakeholders in a world where there's a lot of data, a lot of meetings, and a lot of dashboards. We help create clarification, and most importantly, think about making things much more proactive than reactive. It's been amazing thinking about how we go from a reactive world to a proactive world? How do we go from a dashboard to an actionable next step? And it's been phenomenal partnering with an organization like Common Spirit to show the world that this is not only possible, but there are incredible outcomes with it.
Could you tell me how this platform works and the benefits it provides to healthcare organizations?
In today's world, there is so much information, so many sources where data comes from. There are unstructured datasets, like contracts, for example, where it might be sitting on someone's desk, in a PDF, in a big repository of files, or external data on the internet. There's structured data. Maybe it's sitting in an ERP. Maybe it's sitting in another system of record, like an EMR. Then there is context in people's heads. If you take all of that, analyze it, and present it to a meeting somewhere, people make decisions, and actions take place. Instead of that, what Midstream does is sort of sequences all of that data, unstructured, structured data, even publicly available data. It takes context from the people working behind the scenes in the administrative layer, does the analytics in the background, and then proactively says, "Hey, here's a next step."
It's sort of going from the era when people used to print maps and hoped for a good sense of direction to Google Maps, which is a lot more prescriptive. I think that paradigm hasn't been really possible in financial decisions.
What Midstream does, for example, when you buy a really expensive device, it looks at not just the contract, but it also looks at the financial data, and says: “Hey, in the moment, we've identified some waste that could occur. Let's go ahead and remedy it. Are you interested in this particular next step?”
In our industry, there are actually many ways to save money without changing workflows or people's jobs. There are just decisions that are sitting on the table that, if you had gone through the data, you would identify that it happens today in a very manual way.
Could you tell us how this platform may differ from other platforms?
Why we're so excited about this step function change is that the system actually sequences all of the data from the contract. It's based on market share data. It's based on volume; it's based on lots of things. It's able to connect the dots between the contract, which is a static PDF, and the transactional data and all the decisions that are being made.
There are some phenomenal outcomes where we've shown that by taking simple next steps that are already in the contract, you can save dollars for the industry. There's a long affordability crisis in healthcare. Healthcare is too expensive.
Can you elaborate about the shift from analytics to agentic action, or AI?
There is a lot of complexity in devices and drugs, and a lot of decisions are being made. It's very cumbersome. The agentic world says: “Hey, let the agent read all the data. Let the agent analyze the data, and instead of having 10 meetings, let me just ask the agent questions about the data.” Now, if you want to understand the why behind it, you can choose to do that on your own time. That's why agents are so interesting. It can go from just cruise control and lane assist to more of an augmented copilot. It's that sort of step-by-step of how do we take all these little decisions and let people focus on the big ones, where it shouldn't be a human's job to read 800 pages
Could you tell me a bit about the partnership with CommonSpirit?
CommonSpirit is one of the largest not-for-profits in the country, and its mission to advance human kindness aligns with ours. Our mission is about creating zero waste in American healthcare and around the world, and maximizing savings.
For us, this is not just a one-off pilot; it's a long-term partnership where we want this to really apply in many different areas. We started with supply chain, but we genuinely think that if we do this the right way, others will follow. Other health systems will follow. Because it's not just a one-off hospital, you know, it's to, you know, hundreds of hospitals. Their leadership team is incredibly transformational and forward-thinking, which we genuinely enjoy.
When did you start implementing the system?
We started implementing this in a big way last year. We really got to implement and see the results in 2025.
Could you speak to some of the results you have seen?
We're very proud of our outcomes. First, we think that in an ocean of AI companies, leading with results really matters because that's what people really care about at the end of the day. And so, we're very proud of it. We think a lot about speed-to-value.
Can you talk about some of the challenges you faced and how you solved those?
I think people think a lot about agents and AI, but it's the data story that feeds into it that makes a great application. That's step one. Step two is…it's about the people. How do people change their decisions? The last thing is that the pace of change today is so dramatic that every three days in AI feels like a new year.
Thinking about that, what do you foresee for the future?
For us, all of this is about how you achieve outcomes and how you reduce waste. I think there are a lot of people in our industry who are very burnt out. I don't think we talk about operator burnout and administrative burnout, because healthcare is so complicated in America. There are so many decisions to make, from little decisions on purchasing or execution of a contract, to thinking about how new drugs, devices, and technology are changing. I think that is probably what I'm most excited about: this intelligence layer that's proactive and assistive and can connect the dots in a very siloed environment, in a very big healthcare ocean.
How has your international experience helped you with this development?
It's a great perspective. I think innovation in Silicon Valley and for healthcare is about U.S. healthcare, because there are the complexities and the incentive models. They're so complex that you spend all your energy here. I think we have an affordability problem around the world. When we think about our mission to achieve zero waste in healthcare and maximize savings for society, I think this can really scale across the globe. We are really thinking about financial decisions, and I think this is universal.
What is your advice for healthcare leaders?
I grew up in India and Silicon Valley, and I genuinely think AI is a technical revolution. I think it's a platform shift. I think it's genuinely going to be great for mankind, harnessed the right way. But we have to think about the humans on the other side who are using these things and approach it with an understanding of all the other aspects of their workflows, their priorities. We have to be thoughtful of governance.
About the Author

Pietje Kobus-McAllister
Pietje Kobus-McAllister has an international background and experience in content management and editing. She studied journalism in the Netherlands and Communications and Creative Nonfiction in the U.S. Pietje joined Healthcare Innovation in January 2024.

