Rise of New COVID Variants Sparks Concern Across U.S. Regions

Cases are escalating in nine U.S. states
Oct. 2, 2025
2 min read

Key Highlights

  • New COVID variants XFB (Stratus) and NB.1.8.1 (Nimbus) are contributing to rising infection rates across multiple U.S. states.
  • Wastewater surveillance shows 'very high' COVID levels in Nevada, Utah, Delaware, and Connecticut, indicating widespread community spread.
  • The XFG variant now accounts for approximately 78 percent of cases in the U.S., up from 14 percent two months ago, signifying rapid dominance.
  • Regions with low vaccination rates or no prior infection are particularly vulnerable to these emerging variants.

New COVID variants are driving a rise in infections, especially in the northeast over the past few weeks. In the US, nationwide Covid wastewater levels, used to measure the community spread of a virus, are 'moderate,' according to the Centers for Disease Control and Prevention (CDC), but Nevada, Utah, Delaware, and Connecticut are all recording 'very high' levels, The Daily Mail reported.

The strains are XFB, dubbed Stratus, and NB.1.8.1, known as Nimbus. Cases are escalating in nine U.S. states: New York, New Jersey, Delaware, Vermont, Michigan, Wisconsin, Minnesota, North Dakota, and South Dakota, according to the CDC, as reported by Newsweek’s Suzanne Blake this week. Those who are unvaccinated or have never contracted COVID-19 may be particularly vulnerable, Blake wrote.

According to the CDC, the XFG variant accounted for approximately 78 percent of cases in the U.S., Chelsea Madden reported for The Telegraph. Two months prior, it had made up only 14 percent of cases,

The World Health Organization (WHO) reported that XFG made up 68 percent of all submitted sequences in the week ending September 7, which, the organization noted, was an increase from 61 percent in the week ending August 10.

About the Author

Pietje Kobus

Pietje Kobus

Pietje Kobus has an international background and experience in content management and editing. She studied journalism in the Netherlands and Communications and Creative Nonfiction in the U.S. Pietje joined Healthcare Innovation in January 2024.

Sign up for our eNewsletters
Get the latest news and updates