Facilitated by the growing digitization of medicine and biology, precision medicine is an emerging approach to healthcare that accounts for individual variability at the molecular level, environmental exposures, and lifestyle behaviors. With increasing provider investment in establishing precision medicine strategies, health systems have sought Deloitte Consulting’s expertise with operational definitions of precision medicine service lines (the what), implementation roadmaps to operationalize precision medicine programs (the how), and evaluation of technology vendors and industry partners in the space (with whom).