Decision support tool boosts genetic testing knowledge in breast cancer patients

Oct. 5, 2018

Genetic testing after a breast cancer diagnosis can offer clues to individualized treatment decisions for a patient and her treatment team.

But many patients aren’t aware it exists and could be missing out on that opportunity, according to a new study published in Cancer.

A team at the University of Michigan Rogel Cancer Center recently sought to determine how much newly-diagnosed cancer patients understand about the benefits of genetic testing after a diagnosis.

Their other objective: To find out whether a decision support tool would be helpful in improving that knowledge going forward.

To gain insight, researchers enrolled 496 patients with newly diagnosed early stage breast cancer from multiple practices in four states. Patients were randomized to view a tailored, interactive decision tool called iCanDecide or to view similar information on a static website.

The tool, presented as a website, was focused on informing women about their locoregional and systemic treatment. It also had a module about genetic testing that featured information about types of genetic testing, the implications of test results for treatments and the importance of receiving genetic counseling.

About a month after viewing the tool, patients were surveyed to determine their knowledge about genetic testing, including the probability of carrying a BRCA1 and/or BRCA2 variant, the purposes and benefits of genetic testing, and the implications on cancer recurrence, treatment decisions and family risk.

Women who used the iCanDecide tool had an 11.4% increase in genetic testing knowledge compared to those who did not, researchers found.

Still, overall rates of knowledge in both arms of the study were relatively low.

The results underscore the importance of pairing tools like iCanDecide with genetic counseling, which remains a key component of informed decision making for genetic testing in patients with breast and other cancers, says Sarah T. Hawley, Ph.D., MPH, a professor of internal medicine at Michigan Medicine.

“We need ways and tools to support genetic counselors in helping educate cancer patients and, eventually, their family members,” says Hawley, who co-authored the study. “Although not a replacement for professional advice, our findings suggest that online tools can provide a useful complement.”

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