The first human corneas have been 3D printed by scientists at Newcastle University, U.K.
It means the technique could be used in the future to ensure an unlimited supply of corneas.
As the outermost layer of the human eye, the cornea has an important role in focusing vision.
Yet there is a significant shortage of corneas available to transplant, with 10 million people worldwide requiring surgery to prevent corneal blindness as a result of diseases such as trachoma, an infectious eye disorder.
In addition, almost 5 million people suffer total blindness due to corneal scarring caused by burns, lacerations, abrasion, or disease.
The proof-of-concept research, published in Experimental Eye Research, reports how stem cells (human corneal stromal cells) from a healthy donor cornea were mixed together with alginate and collagen to create a solution that could be printed, a ‘bio-ink’.
Using a simple low-cost 3D bio-printer, the bio-ink was successfully extruded in concentric circles to form the shape of a human cornea. It took less than 10 minutes to print.
The stem cells were then shown to culture—or grow.
The dimensions of the printed tissue were originally taken from an actual cornea. By scanning a patient’s eye, they could use the data to rapidly print a cornea which matched the size and shape.
