Genetic tests for certain cancers leave potential patients with tough decisions

Sept. 5, 2018

Genetic testing is now helping patients stop cancer before it strikes, including stomach cancer, which will kill nearly 11,000 Americans this year. But the testing is also forcing some to make a difficult decision.

This year in the U.S., an estimated 28,000 people—17,750 men and 10,250 women—will be diagnosed with stomach cancer. An estimated 10,960 people—6,720 men and 4,240 women—will die from the disease.

The 5-year survival rate for people with stomach cancer is 30%. This statistic reflects the fact that most people with stomach cancer are diagnosed after the cancer has already spread to other parts of the body.

When Aaron Rosenberg’s aunt, Alice Grossman, was diagnosed with a genetic form of stomach cancer two years ago, a look at his family tree set off alarm bells.

Genetic testing revealed he carried a rare mutation that gave him a 55% to 70% chance of developing stomach cancer. His mother, Elaine, also carries the mutation.

Rosenberg then faced a decision: Do nothing and hope for the best, or do something dramatic, just like Angelina Jolie, who underwent a double mastectomy after testing positive for a gene that carries a 50% chance of breast cancer.

With a husband and two young boys at home, Rosenberg chose not to roll the dice.

In August 2017, surgeons removed his stomach, and connected his esophagus to the small intestine. Even though his stomach looked normal to the eye, a microscopic examination showed a surprise.

“There were 14 sites of, what was described to me as, stage 1A cancer,” Rosenberg said.

Meaning he was going to get stomach cancer—in fact, he was already developing it.

He’s doing well, but has lost 30 pounds on a restricted diet of seven or eight small meals a day. A salad platter with a whole bagel used to be his typical lunch. Now, it’s just a scoop of tuna fish.

CBS News has the full story

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